Synthesis and in vitro cytotoxicity of novel ursolic acid derivatives

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Abstract

In an effort to improve potential hepatoprotective and anti-tumor activities, eight novel ursolic acid (UA) derivatives were designed and synthesized with substitution at positions of C-3, C-11and C-28 of UA. Their structures were confirmed using IR, MS and 1H-NMR and elemental analysis. Their in vitro cytotoxicity against various cancer cell lines (HeLa, SKOV3 and BGC-823) was evaluated by the standard MTT assay. Among them, compound 13 exhibited more potent cytotoxicity than ursolic acid.

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Meng, Y., Song, Y., Yan, Z., & Xia, Y. (2010). Synthesis and in vitro cytotoxicity of novel ursolic acid derivatives. Molecules, 15(6), 4033–4040. https://doi.org/10.3390/molecules15064033

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