A methanolic extract of Agrimonia eupatoria (Rosaceae) significantly attenuated glutamate-induced oxidative stress in HT22 hippocampal cells. A new flavonoid, characterized as kaempferol 3-O-β-D-(2″-O-acetyl- 6″-(E)-p-coumaroyl)-glucopyranoside (2″-acetyltiliroside (1), was isolated from the methanolic extract of A. eupatoria stems together with nine known flavonoids. Compounds 4, 7, 8 and 9 all showed a neuroprotective effect on glutamate-induced toxicity in HT22 cells.
CITATION STYLE
Lee, K. Y., Hwang, L., Jeong, E. J., Kim, S. H., Kim, Y. C., & Sung, S. H. (2010). Effect of Neuroprotective Flavonoids of Agrimonia eupatoria on Glutamate-Induced Oxidative Injury to HT22 Hippocampal Cells. Bioscience, Biotechnology and Biochemistry, 74(8), 1704–1706. https://doi.org/10.1271/bbb.100200
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