LIANA+ provides an all-in-one framework for cell–cell communication inference

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Abstract

The growing availability of single-cell and spatially resolved transcriptomics has led to the development of many approaches to infer cell–cell communication, each capturing only a partial view of the complex landscape of intercellular signalling. Here we present LIANA+, a scalable framework built around a rich knowledge base to decode coordinated inter- and intracellular signalling events from single- and multi-condition datasets in both single-cell and spatially resolved data. By extending and unifying established methodologies, LIANA+ provides a comprehensive set of synergistic components to study cell–cell communication via diverse molecular mediators, including those measured in multi-omics data. LIANA+ is accessible at https://github.com/saezlab/liana-py with extensive vignettes (https://liana-py.readthedocs.io/) and provides an all-in-one solution to intercellular communication inference.

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Dimitrov, D., Schäfer, P. S. L., Farr, E., Rodriguez-Mier, P., Lobentanzer, S., Badia-i-Mompel, P., … Saez-Rodriguez, J. (2024). LIANA+ provides an all-in-one framework for cell–cell communication inference. Nature Cell Biology, 26(9), 1613–1622. https://doi.org/10.1038/s41556-024-01469-w

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