Treatment outcomes in Polish COVID-19 patients requiring hospitalisation in the intensive care unit: a single-centre retrospective study

Abstract

Background: COVID-19 has disturbed the functioning of Polish healthcare for the past two years. Due to the high proportion of patients requiring admission to the intensive care unit (ICU), these wards are particularly overwhelmed and are considered the bottleneck of the healthcare system. The aim of this study was to describe clinical outcomes of critically ill patients treated in a single tertiary ICU in Poland, assess factors associated with mortality and compare outcomes of patients treated during the 2ndand 3rdwaves of the pandemic. Methods: This is a retrospective single-centre study including patients admitted to the ICU between October 2020 and May 2021 (the 3rdwave) with confirmed SARS-CoV-2 infection. Patients were followed up until death or 90 days after ICU admission. The coprimary endpoints of this study included ICU, 30-day and 90-day mortality. Results: We enrolled 108 patients at a mean age of 64.3 (SD = 12) years, the majority of whom were male (63.9%). Mortality in the ICU, after 30 days and 90 days was 44.4% (48/108), 50.0% (54/108), and 57.9% (62/108), respectively. Mortality at 90 days was associated with increasing age (OR = 3.97, 95% CI: 1.87-8.41) and was significantly higher during the 2ndwave (65.6 vs. 46.5%, log-rank P = 0.043) compared to the 3rdwave of the pandemic. Conclusions: This retrospective single-centre study confirms the high mortality rate among critically ill patients with COVID-19. Moreover, it suggests a significant association between 90-day mortality and increasing age as well as differences in mortality between the 2ndand 3rdwaves of the pandemic in Poland.