A novel cytotoxic physalin from physalis angulata

Abstract

Bioassay-guided fractionation from the whole plant of Physalis angulata led to the isolation of a novel physalin, 25-hydroxylisophysalin B (1), together with three megastigmane glucosides (2-4) and eight known physalins (5-12). The structure of compound 1 was elucidated by analysis of spectroscopic data. All of the compounds exhibited cytotoxic activities against MCF-7 human mammary cells and HepG2 human hepatoma cells.