Influência da adição da goma arábica em filmes isolados de polímero acrílico. Estudo das propriedades de intumescimento e de permeabilidade

Abstract

Arabic gum combined with polymeric acrylic Eudragit RS30D® in isolated films for film coating, were obtained and investigated as potential material adapted for drug delivery systems. They were prepared aqueous dispersions of 4% (p/v), the triethyl citrate (20% w/w of the methacrylate polymer) it was used with plasticizer. Sample of dispersions were poured over plate of Nylon covered with Teflon and placed in an air circulated oven at 60 °C. Determination of the swelling index (Is%) in fluids of gastric (SGF) or intestinal simulation or intestinal (SIF), and the permeability to the water vapour (TVA) were investigated. An increase in the amount of added polysaccharide favored the degree of hydration/swelling and permeability of the formed films. These observed particularities suggest that the films constituted by these combinations guarantee accessibility with larger intensity when compared individually to the polymethacrylate, condition that is indispensable for effective biodegradation, especially to the regions distal of gastrointestinal tract.