Since the discovery of SERS nearly thirty years ago, it has progressed from model-system studies of pyridine to state-of-the-art surface-science studies coupled with real-world applications. We have demonstrated a SERS-based glucose sensor as an example of the latter. A SERS-active surface functionalized with a mixed SAM was shown to partition and departition glucose efficiently. The two components of the SAM, DT and MH, provide the appropriate balance of hydrophobic and hydrophilic groups. The DT/MH-functionalized SERS surface partitioned and departitioned glucose in less than 1 min, which indicates that the sensor can be used in real-time, continuous sensing. Furthermore, quantitative glucose measurements, in the physiological concentration range, in a mixture of interfering analytes and in bovine plasma were also demonstrated. Finally, the DT/MH-functionalized SERS surface showed temporal stability for at least 10 days in bovine plasma, making it a potential candidate for implantable sensing.
CITATION STYLE
Yonzon, C. R., Lyandres, O., Shah, N. C., Dieringer, J. A., & Duyne, R. P. (2006). Glucose Sensing with Surface-Enhanced Raman Spectroscopy. In Surface-Enhanced Raman Scattering (pp. 367–379). Springer Berlin Heidelberg. https://doi.org/10.1007/3-540-33567-6_19
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