Pathogenesis of Cancer: Cancer Reparative Trap

Abstract

Cancer is one of the leading causes of death in the world while the long-term prognosis is still un-favorable, despite the enormous efforts in the search for effective anti-cancer drugs. We think that the obstacle for creating of effective anti-cancer drugs could be existing idea that the basis of can-cer is caused by the damage of the genetic apparatus of the cell. In this paper, we present the pa-thogenesis of cancer which is based on the formation of the special sustainable pathophysiological state of the organism what we call the state of " cancer reparative trap " . The essence of this patho-physiological state of the organism is in the reparative orientation of the immune system of cancer patients, when constant tissue repair is accompanied by systemic suppression of the anti-tumor immunity. Specifically, during the long-term exposure to carcinogens (exogenous and/or endo-genous), the continuous tissue damage occurs which induces permanent stimulation of cell proli-feration (imbalanced Th1 < Th2 lymphocytes, M1 < M2 macrophages, inflammation, angiogenesis, etc.) in order to repair the tissues damaged. At the same time, tissue repair is necessarily accom-panied by the suppression of anti-tumor immunity (increase in T-regulatory cells, imbalanced Th1 < Th2 lymphocytes, M1