RBP2 promotes adult acute lymphoblastic leukemia by upregulating BCL2

4Citations
Citations of this article
13Readers
Mendeley users who have this article in their library.

Abstract

Despite recent increases in the cure rate of acute lymphoblastic leukemia (ALL), adult ALL remains a high-risk disease that exhibits a high relapse rate. In this study, we found that the histone demethylase retinoblastoma binding protein-2 (RBP2) was overexpressed in both on-going and relapse cases of adult ALL, which revealed that RBP2 overexpression was not only involved in the pathogenesis of ALL but that its overexpression might also be related to relapse of the disease. RBP2 knockdown induced apoptosis and attenuated leukemic cell viability. Our results demonstrated that BCL2 is a novel target of RBP2 and supported the notion of RBP2 being a regulator of BCL2 expression via directly binding to its promoter. As the role of RBP2 in regulating apoptosis was confirmed, RBP2 overexpression and activation of BCL2 might play important roles in ALL development and progression.

Cite

CITATION STYLE

APA

Wang, X., Zhou, M., Fu, Y., Sun, T., Chen, J., Qin, X., … Chen, C. (2016). RBP2 promotes adult acute lymphoblastic leukemia by upregulating BCL2. PLoS ONE, 11(3). https://doi.org/10.1371/journal.pone.0152142

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free