Magnetic resonance nanotheranostics of guerin’s carcinoma

Abstract

We proposed a new technology of nanotheranostics that is combination of magnetic resonance therapy and chemotherapy during moderate hyperthermia below 40 ºC inside tumor with diagnostics by magnetic resonance imaging. As nanotheranostics agent the multifunctional magnetosensitive nanocomplex consisted of nanoparticles containing Fe3O4 with diameters < 50 nm and antitumor drug doxorubicin was used. The synthesis of multifunctional magneto-sensitive nanocomplex was performed in a magnetomechanical reactor. We conducted a detailed imaging study of transplanted Guerin’s carcinoma in rats during treatment with magnetic nanotherapy. We showed that treatment with magneto-mechano-chemically synthesized magnetosensitive nanocomplexes based on Fe3O4 nanoparticles conjugated with the antitumor agent doxorubicin and followed by irradiation with local electromagnetic irradiation resulted in a better outcome than treatment with conventional doxorubicin or treatment with magnetic nanocomplexes without electromagnetic irradiation. An analysis of magnetic resonance images obtained over time showed that the application of local electromagnetic irradiation did not alter the position of magnetic nanocomplexes in the tumor.