Abstract
This chapter begins by describing the human stress response in order to provide the context for understanding the psychobiology of PTSD. It then discusses PTSD-related abnormalities in the brain function and structure as well as alterations in the adrenergic, serotonergic, and hypothalamic--pituitary--adrenocortical (HPA) systems. The current state-of-the-art regarding efficacy of pharmacotherapy for PTSD is broadly reviewed with respect to: antidepressants, antiadrenergic agents, anticonvulsants/mood stabilizers, antipsychotic agents, and anxiolytic medications. Finally, genetic and epigenetic aspects of resilience are briefly addressed.
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CITATION STYLE
Friedman, M. J. (2015). Pharmacological Treatments for PTSD. In Posttraumatic and Acute Stress Disorders (pp. 93–114). Springer International Publishing. https://doi.org/10.1007/978-3-319-15066-6_5
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