Synthesis and biophysical analysis of modified thymine-containing DNA oligonucleotides

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Abstract

We report the synthesis of a 5-formyl-2′-deoxyuridine (5fU) phosphoramidite and the preparation of oligonucleotides comprising all known, naturally observed eukaryotic thymidine modifications. Biophysical characterization of the synthetic oligonucleotides indicates that 5fU, but not the other T-derivatives, can alter DNA structures.

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Kawasaki, F., Murat, P., Li, Z., Santner, T., & Balasubramanian, S. (2017). Synthesis and biophysical analysis of modified thymine-containing DNA oligonucleotides. Chemical Communications, 53(8), 1389–1392. https://doi.org/10.1039/c6cc08670e

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