New chemical-enzymatic technology based on the modification of the bacterial polysaccharide K5 from Escherichia coli leads to the synthesis of a number of heparin/heparan sulfate-like molecules with different biological activities. With this technology, two families of sulfated compounds were synthesized, which differ in their uronic acid content. The first group contains only glucuronic acid, whereas the second group contains about 50% iduronic acid following epimerization by immobilized recombinant C5 epimerase. This has led to the development of various anticoagulant and nonanticoagulant K5 derivatives endowed with different - and sometimes highly specific - antitumor, antiviral, and/or anti-inflammatory activities. © 2012 Springer-Verlag Berlin Heidelberg.
CITATION STYLE
Oreste, P., & Zoppetti, G. (2012). Semi-synthetic heparinoids. Handbook of Experimental Pharmacology, 207, 403–422. https://doi.org/10.1007/978-3-642-23056-1_18
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