Minor Cucurbitane-Glycosides from Fruits of Siraitia grosvenori (Cucurbitaceae)

Abstract

From fruits of Siraitia grosvenori, a Chinese medicinal plant, a new minor glycoside and four known minor cucurbitane glycosides, siamenoside I (sweet), 11-oxo-mogroside V (sweet), and mogrosides IIE and IIIE (both tasteless) were isolated together with mogrosides IV and V (both sweet) previously isolated from this fruit by Arihara et aL Structure of the new tasteless glycoside called mogroside III was elucidated as 3-0-/J-D-glucopyranosyl-24-0-/l-gentiobiosyl-mogrol. The relative sweetness of siamenoside I to sucrose was estimated x 563, making this the sweetest compound among the cucurbitane-glycosides so far isolated. The structure-taste relationship of cucurbitane-glycosides is also described. © 1990, The Pharmaceutical Society of Japan. All rights reserved.