Stringent control of NFE2L3 (Nuclear Factor, Erythroid 2-Like 3; NRF3) protein degradation by FBW7 (F-box/WD Repeatcontaining Protein 7) and glycogen synthase kinase 3 (GSK3)

Abstract

Background: NFE2L3 is involved in carcinogenesis, stress response, differentiation, and inflammatory processes. Results: NFE2L3 is polyubiquitinated via the E3 ubiquitin ligase FBW7, which regulates its turnover. This process requires prior phosphorylation by GSK3. Conclusion: NFE2L3 is tightly regulated by FBW7 and GSK3 through polyubiquitination. Significance: Our data highlight the regulation of NFE2L3 by FBW7 and GSK3 and its potential role in cellular stress response.