In vitro dissolution kinetic for mycophenolic acid derivatives tablets

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Abstract

Mycophenolate mofetil (MMF) and mycophenolate sodium (MPS) are an ester and a salt of mycophenolic acid. They have different kinetic in vivo characteristics due to differences in molecular structures, physicochemical properties and formulations administered. In this study, dissolution profiles of reference products were tested in different media to evaluate the effect of pH, kinetic dissolution and the best statistical model that can be used to predict the release of both drugs. The drug release was determined by using a validated ultraviolet spectrophotometry method, λ 250 nm. The method showed to be selective, linear, precise and accurate for MMF in 0.1 M HCl and MPS in sodium phosphate buffer pH 6.8. Dissolution kinetics models of zero order, first order, Higuchi, Hixson-Crowell and Weibull were applied to data in order to select the best fit by linear regression. The regression parameters were estimated and the models were evaluated with the results of residuals and coefficient of determination. The residuals obtained from dissolution kinetics models were random, uncorrelated, and normally distributed with constant variance. The R2 values (74.7% for MMF and 95.8% for MPS) demonstrated good ability of the Weibull regression to explain the variability and to predict the drugs' release.

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Costa, A. L. de O., Enéas, P. C. R., Miranda, T. A., Mingoti, S. A., Soares, C. D. V., & Pianetti, G. A. (2013). In vitro dissolution kinetic for mycophenolic acid derivatives tablets. Brazilian Journal of Pharmaceutical Sciences, 49(2), 311–319. https://doi.org/10.1590/S1984-82502013000200013

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