Effect of chemically-synthesized silver nanoparticles(AG-NP) on glycemic and lipidemic status in rat model

Abstract

The aim of present study was to investigate the effects of chemically synthesized of silver nanoparticles (Ag-NP) using citrate on selected blood biochemical parameters includes glucose, total cholesterol, triglyceride and total protein in rats model. In this study Ag-NP was synthesized with the usage of chemical reduction method. Laboratory rats were divided into four groups; control, placebo, and groups received 100 and 200 mg/kg BW of Ag-NP. Blood samples were taken, 15 days after administration, and separated serum was used for determination of biochemical measures. Greater dosage of Ag-NP (200 mg/ kg BW) causes mortality in experimental group, due to possible toxic effect of chemically synthesized Ag-NP. In serum biochemical measures infusion of Ag-NP had decreases serum glucose level (92 and 91 ml/dl in compared with control: 109 ml/dl), and total cholesterol and triglyceride had increases following Ag-NP administration (P< 0.01). In conduction, peripherally administration of chemically-synthesized Ag- NP in 100-200 mg/Kg of BW dosages, cause hypoglycemic and hyper-lipidemic effects, due to increases peripheral glucose and decreases total cholesterol and triglyceride levels in rat model. The administration of greater dosage may cause mortality of experimental animals.