Luteal support: What to use when?

Abstract

Supraphysiological hormonal profiles are the cause of luteal defect observed in stimulated IVF cycles. Hence it is essential to support the luteal phase in stimulated cycles for which different forms of support are available. Progesterone and human chorionic gonadotropins (hCGs) so far have been the ideal supports for pregnancy. HCG results in higher incidence of ovarian hyperstimulation. Luteal phase support with progesterone results in increase in implantation and pregnancy rates. For now, progesterone seems to be the best option as luteal phase support. Oral progesterone is associated with reduced bioavailablity. Vaginal progesterone is associated with increased at-site concentration.