Nectins and nectin-like molecules: Roles in cell adhesion, polarization, movement, and proliferation

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Abstract

Nectins and nectin-like molecules (Necls) are immunoglobulin-like cell adhesion molecules that constitute families containing four and five members, respectively. All members, except for Necl-5, trans -interact homophilically. Furthermore, all members, including Necl-5, trans -interact heterophilically with their respective specific partners among the members. Necl-5 regulates cell movement and proliferation cooperatively with integrin α vβ3 and growth factor receptors. Nectins function as cell-cell adhesion molecules at a variety of cell-cell junctions, including adherens junctions, and regulate the initial step of cell-cell junction formation. Nectins and integrin αvβ3 are further involved in the cross-talk between cell-matrix and cell-cell junctions. Thus, both nectin and Necl family members play important roles in fundamental cellular functions, including cell adhesion, polarization, movement, and proliferation. © 2006 IUBMB.

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Ogita, H., & Takai, Y. (2006). Nectins and nectin-like molecules: Roles in cell adhesion, polarization, movement, and proliferation. In IUBMB Life (Vol. 58, pp. 334–343). https://doi.org/10.1080/15216540600719622

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