On the Safety of Filamentous Fungi with Special Emphasis on Trichoderma reesei and Products Made by Recombinant Means

Abstract

. Gene expression by yeasts versus filamentous fungi -- perspectives and challenges -- Ascomycetes as fungal workhorses for industry -- Industrial uses of Zygomycetes -- Biotechnological application of basidiomycetes -- Mining fungal genomes for improvement of gene expression -- Targets of strain improvement in fungi -- Sexual development for strain improvement of fungi -- Using chromatin modification in biotechnology -- Awakening silent clusters for expression secondary metabolites -- High throughput construction of genetically modified fungi -- Regulatory mechanisms in enzyme production by fungi -- Regulatory mechanisms in production of metabolites by fungi -- Production of enzymes and performance proteins in Trichoderma reesei -- Aspergilli -- versatile producers of proteins and metabolites -- Fungal gene expression systems for antibiotics production -- Novel fungal gene expression systems for the future of biotechnology -- Designing the ideal production host -- strategies and challenges in strain improvement -- Challenges and perspectives in expression of enzymes and performance proteins -- Exploiting natural selection -- are novel fungal isolates the future of industrial biotechnology? -- Targeted genetic modification of organisms versus random mutagenesis -- will societal acceptance influence industrial strategies?.