Interfacial impedance sensor employing bio-activated microbeads and NiHCF-coated interdigitated microelectrodes: A model analysis

Abstract

An impedance sensor based on NiHCF-coated interdigitated microelectrodes is presented as a promising solution for ultra-low level pathogen detection. The micro sensor employs micro-sized beads, which are coated with anti-pathogen specific antibodies, to achieve the high-sensitive detection through the amplified variations of the interfacial impedance. The effect of beads on the microelectrodes solution interface and subsequent impedance change were analyzed and demonstrated by fitting the experimental data to an equivalent electrical circuit model. © 2011 Springer-Verlag Berlin Heidelberg.