Immune Involvement in Autism Spectrum Disorder as a Basis for Animal Models

  • Y. Hsiao E
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Abstract

Several of the environmental stimuli suggested to play a role in the pathogenesis of ASD involve altered immune responses during gestation. In this review, we discuss maternal immune activation as a primary risk factor for ASD, with an emphasis on recent findings from animal models of prenatal immune challenges. We further address the presence of autoantibodies as an additional immune-related autism risk factor, drawing upon work done in rodent and monkey models. We then explore the intersection between genetic and environmental susceptibility, with a focus on gene-environment interactions and immune involvement, in genetic risk factors for autism. Finally, we provide emerging evidence for the role of immune dysregulation in the pathogenesis of ASD.

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APA

Y. Hsiao, E. (2012). Immune Involvement in Autism Spectrum Disorder as a Basis for Animal Models. Autism- Open Access, 01(S1). https://doi.org/10.4172/2165-7890.s1-003

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