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Alteration of leptin-induced STAT3 activation in the brain of senescence-accelerated mouse (SAM) P8

Biological and Pharmaceutical Bulletin (2005) 28(8) 1514-1516
DOI: 10.1248/bpb.28.1514
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Abstract

We used senescence-accelerated mouse prone 8 (SAMP8), a useful model of accelerated aging, to investigate the responsiveness to leptin with aging. The state of leptin-induced STAT3 phosphorylation in the hypothalamus was found to be higher in SAMP8 than in SAMR1, a control mouse showing normal aging, at 14 - 18 months of age but not at 2 months of age. Moreover, leptin receptor Ob-Rb expression in the hypothalamus was up-regulated in SAMP8. The results indicate that leptin sensitivity increases with aging in the SAM mouse brain. © 2005 Pharmaceutical Society of Japan.

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CITATION STYLE

APA

Hosoi, T., Okuma, Y., Ono, A., & Nomura, Y. (2005). Alteration of leptin-induced STAT3 activation in the brain of senescence-accelerated mouse (SAM) P8. Biological and Pharmaceutical Bulletin, 28(8), 1514–1516. https://doi.org/10.1248/bpb.28.1514

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