Prolonged low dose indomethacin for persistent ductus arteriosus of prematurity

51Citations
Citations of this article
11Readers
Mendeley users who have this article in their library.

Abstract

A total of 121 infants who required indomethacin for persistent ductus arteriosus in Liverpool and Cambridge over a four year period were randomised to receive either 0·1 mg/kg daily for six days or 0·2 mg/kg every 12 hours for three doses. The groups were of similar birth weight and gestational and postnatal age, though those treated with a low dose were by chance receiving a higher percentage of oxygen at the start of treatment and there were more deaths from bronchopulmonary dysplasia in this group. Of 59 infants treated with the prolonged course 53 (90%) responded initially to indomethacin compared with 48 of 62 (77%) treated conventionally-a difference of 13% (95% confidence interval for the difference 0 to 26%). Of the 53 responders 11 (21%) relapsed after low dose indomethacin, whereas after the shorter course 19 of 48 (40%) relapsed. This difference was significant (95% confidence intervals 3 to 37%). Side effects, mainly gastrointestinal haemorrhage, were similar in both groups. Significantly fewer infants experienced a rise in serum creatinine or urea concentration after treatment with low dose indomethacin. A prolonged low dose course of indomethacin offers advantages over conventional treatment.

Cite

CITATION STYLE

APA

Rennie, J. M., & Cooke, R. W. I. (1991). Prolonged low dose indomethacin for persistent ductus arteriosus of prematurity. Archives of Disease in Childhood, 66(1 SPEC NO), 55–58. https://doi.org/10.1136/adc.66.1_Spec_No.55

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free