Flavonoid Actions on Receptors for the Inhibitory Neurotransmitter GABA

Abstract

Abstract Flavonoids, both naturally occurring and synthetic, are known to have multiple effects on the activation of ionotropic receptors for γ-aminobutyric acid (GABA), the major inhibi- tory neurotransmitter in our brains. They can act as positive or negative allosteric modu- lators, enhancing or reducing the effect of GABA. They can elicit a direct activation of the receptors. They can also act to modulate the action of other modulators. This ability to influence function via their actions on GABA receptors permits a range of effects of flavonoids, including relief of anxiety, anticonvulsant, analgesic and sedative actions.