Abstract
Two new bisindole alkaloids, bisnaecarpamines A (1) and B (2), possessing a vobasine-sarpagine type skeleton were isolated from the bark of Tabernaemontana macrocarpa Jack. Their structures were elucidated by extensive spectroscopic methods and chemical correlation. The absolute configurations of compounds 1 and 2 were established using TDDFT-ECD calculation of the selected isomers. Bisnaecarpamine A exhibited potent antimalarial activity against Plasmodium falciparum 3D7 strain with IC50 value of 28.8 µM. Graphic abstract: [Figure not available: see fulltext.]
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Amelia, P., Nugroho, A. E., Hirasawa, Y., Kaneda, T., Tougan, T., Horii, T., & Morita, H. (2021). Two new bisindole alkaloids from Tabernaemontana macrocarpa Jack. Journal of Natural Medicines, 75(3), 633–642. https://doi.org/10.1007/s11418-021-01510-4
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