Anticancer agents from Solanum Surattense

Abstract

Two steroids glycosides solamargine (1) and dioscine (2) were isolated from methanolic extract of Solanum surattense and evaluated for their anticancer activity. The structure of the isolated compounds was identified through 1D and 2D NMR techniques, mass spectrometry and in comparison, with the literature values of their spectroscopic data. Both compounds showed the excellent anticancer activity against NIH-3T3 fibroblast cancer cell line with IC50 value of 7.55±1.5 and 3.3±1.9µg/ml respectively which were comparable with control Cyclohexamide which showed the IC50 value of 0.8± 0.2 µg/ml.