Treatment of Relapsed and Refractory Neuroblastoma

Abstract

This volume reviews our current understanding of the genes and biological pathways that contribute to neuroblastoma pathogenesis. It also looks at modern risk-based treatment approaches for these patients, and recent advances in biologically based therapy. Information is summarised and potentials for clinical translation are discussed. Epidemiology; Screening for Neuroblastoma; Genetics; Molecular Cytogenetics; Molecular and Developmental Biology of Neuroblastoma; Cellular Heterogeneity; Clinical Presentation; Pathology of Peripheral Neuroblastic Tumors; Molecular Pathology of Neuroblastic Tumors Based on Genome-wide Expression Analysis; Anatomic and Functional Imaging; Treatment of Neuroblastoma; Treatment of Relapsed and Refractory Neuroblastoma; Management of Neurologic Complications; Immunology and Immunotherapy; Differentiation and Retinoids; Angiogenesis; Experimental Therapeutics and Preclinical Models; Late Effects of Treatment; Perspectives and Future Directions.