Mechanism for iridane skeleton formation from acyclic monoterpenes in the biosynthesis of seoologanin and vindoline in catharanthus roseus and lonicera morrowii

Abstract

Administration of various tritium-labeled monoterpenes to Catharanthus roseus and Lonicera morrowii demonstrated that the loganin (1), secologanin (2) and vindoline (10) of these plants are biosynthesized via cyclization of 10-oxogeranial (11a) or 10-oxoneral (11b) to iridodial (12) and subsequent oxidation to iridotrial(4). © 1984, The Pharmaceutical Society of Japan. All rights reserved.