Insulin resistance of skeletal muscle glucose transport is a key-defect for the development of impaired glucose tolerance and type 2 diabetes. However, it is known that both an acute bout of exercise and chronic endurance exercise training can bring beneficial effects on insulin action in insulin-resistant states. However, little is currently known about the molecular effects of acute exercise on muscle insulin signaling in the post-exercise state in insulin-resistant organisms. This review provides new insight into the mechanism through which acute exercise restores insulin sensitivity, highlighting an important role for inflammatory proteins and S-nitrosation in the regulation of insulin signaling proteins in skeletal muscle.
CITATION STYLE
Pauli, J. R., Cintra, D. E., de Souza, C. T., & Ropelle, E. R. (2009). New mechanisms by which physical exercise improves insulin resistance in the skeletal muscle. Arquivos Brasileiros de Endocrinologia e Metabologia, 53(4), 399–408. https://doi.org/10.1590/s0004-27302009000400003
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