During the past two decades the classical concept of nucleophilic aromatic substitution (S N ipso Ar) has been complemented with a new synthetic methodology (S N H Ar or briefly S N H), enabling one to perform direct functionalization of aromatic C-H bonds and to build new carbon-carbon C(sp 2)-C(sp 3), C(sp 2)-C(sp 2), and C(sp 2)-C(sp) or carbon-heteroatom C(sp 2)-X bonds (X is ON N-, P-, S-, Si-, halogen) through nucleophilic displacement of hydrogen in aromatic and heteroaromatic compounds.
CITATION STYLE
Charushin, V. N., & Chupakhin, O. N. (2014). Metal-Free C–H Functionalization of Aromatic Compounds Through the Action of Nucleophilic Reagents (pp. 1–50). https://doi.org/10.1007/7081_2013_119
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