Making a differential diagnosis between bacterial meningitis and aseptic meningitis is a critical clinical problem. The utility of a cerebrospinal fluid (CSF) lactate assay for this purpose has been debated and is not yet routinely clinically performed. To adequately evaluate this assay, a systematic review and meta-analysis of studies of the CSF lactate concentration as a marker for both bacterial meningitis and aseptic meningitis was performed.
Huy, N. T., Thao, N. T. H., Diep, D. T. N., Kikuchi, M., Zamora, J., & Hirayama, K. (2010). 1Cerebrospinal fluid lactate concentration to distinguish bacterial from aseptic meningitis: A systemic review and meta-analysis. Critical Care, 14(6). https://doi.org/10.1186/cc9395