Cupriavidus metallidurans CH34 has long been known for its temperature-induced mutagenesis and mortality phenotype (TIMM), for which a genetic origin has been suggested repeatedly. In this report, we present microscopic-based evidences that the TIMM process actually starts with a septation defect, leading to aberrant cell morphologies. Moreover, the septation defect of CH34 could be induced by NaOCl, thus showing that the TIMM phenotype may be part of a more general stress response. Sequence analysis of a TIMM survivor exhibiting a recurrent recognizable lysA mutation ruled out the possibility of a genetic ground linking TIMM survival and peptidoglycan synthesis. © 2014 Federation of European Microbiological Societies. Published by John Wiley & Sons Ltd. All rights reserved.
CITATION STYLE
Arroua, B., Bellanger, X., Guilloteau, H., Mathieu, L., & Merlin, C. (2014). Atypical stress response to temperature and NaOCl exposure leading to septation defect during cell division in Cupriavidus metallidurans CH34. FEMS Microbiology Letters. Blackwell Publishing Ltd. https://doi.org/10.1111/1574-6968.12399
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