Protein Adsorption and Adhesion of blood platelets on silicone rubber under static and dynamic flow conditions

Abstract

Understanding the spontaneous protein adsorption on biomaterial surfaces is a key element to evaluate their thrombogenicity and especially their propensity to trigger the adhesion of blood platelets (thrombocytes). In this work, the adhesion of two proteins (bovine fibrinogen and bovine serum albumin) on silicone rubber and the thrombocyte adhesion on different preadsorbed protein layers has been investigated under static and dynamic flow conditions. It has been shown that proteins do not adhere equally to silicone rubber and that both the composition of protein layer and the flow conditions influence the thrombocyte adhesion.