A workflow for selection of single nucleotide polymorphic markers for studying of genetics of ischemic stroke outcomes

4Citations
Citations of this article
16Readers
Mendeley users who have this article in their library.

Abstract

In this paper we propose a workflow for studying the genetic architecture of ischemic stroke outcomes. It develops further the candidate gene approach. The workflow is based on the animal model of brain ischemia, comparative genomics, human genomic variations, and algorithms of selection of tagging single nucleotide polymorphisms (tagSNPs) in genes which expression was changed after ischemic stroke. The workflow starts from a set of rat genes that changed their expression in response to brain ischemia and results in a set of tagSNPs, which represent other SNPs in the human genes analyzed and influenced on their expression as well.

Cite

CITATION STYLE

APA

Khvorykh, G., Khrunin, A., Filippenkov, I., Stavchansky, V., Dergunova, L., & Limborska, S. (2021). A workflow for selection of single nucleotide polymorphic markers for studying of genetics of ischemic stroke outcomes. Genes, 12(3), 1–9. https://doi.org/10.3390/genes12030328

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free