Aqueous computing with DNA hairpin-based RAM

Abstract

DNA RAM can eliminate the computational overhead of sequence design because the same RAM can be used for various computations once it is made. In this paper, we report a new method to construct RAM by using the hairpin structure of DNA, and the 4-bit RAM that we actually constructed with this method. We conducted an experiment to distinguish all 16 states of the 4-bit RAM, and another to verify our achievement of a successive writing operation. Finally, we performed aqueous computing with this 4-bit RAM. © Springer-Verlag Berlin Heidelberg 2005.