Predicting genotypes from gene expression data

Abstract

The JASON Defense Advisory Panel (JASON), an independent group of scientific advisers to the US Department of Defense (DoD), recently published a report that highlighted the increased sophistication and cost-effectiveness of genome-sequencing technologies and recommended the creation of the necessary infrastructure to perform genetic research on military personnel1. This report is the latest evidence of the DoD's increased interest in the use of genome-sequencing technologies to improve the health and effectiveness of the armed forces; in addition to collecting DNA samples for the identification of remains, the military performs genetic testing for sickle cell anaemia and glucose 6-phosphate dehydrogenase (G6PD) in order to protect at-risk individuals from specific environments or occupations that may trigger adverse effects2.