Insights into bone metabolism from calcium kinetic studies in children

Abstract

Changes in the mineralization rate of the skeleton during childhood are related to normal growth and pubertal development. These may be affected by genetic factors, including race and gender, and by the presence of abnormalities of growth or hormonal abnormalities such as occur in children with chronic illnesses. We have used multicompartmental studies to examine calcium kinetics in healthy children ranging in age from premature infants of 1-2 kg body weight through adolescence. These studies are performed using orally and intravenously administered stable isotopes of calcium. Sample collection requires multiple blood samples to be obtained during the initial time period after isotope dosing, which is feasible in older children using an indwelling catheter. We have found that the peak rate for both bone calcium deposition and removal occurs in girls during the year before menarche. Peak kinetic rates decrease in an exponential fashion postmenarche. On a body-weight basis, the greatest rates of bone calcium deposition and removal are in infants, especially premature infants.