Total synthesis of the big four antibiotics and related antibiotics

Abstract

The first total syntheses of a variety of antibiotics have been accomplished by using carbohydrates as a chiral source. The key target molecules were members of the 'Big Four' classes of antibiotics (macrolides, aminoglycosides, β-lactams and tetracyclines), naphthoquinone antibiotics and their related antibiotics. © 2013 Japan Antibiotics Research Association All rights reserved.