Amino acid region 1000-1008 of factor V is a dynamic regulator for the emergence of procoagulant activity

Abstract

Background: Factor V is activated to factor Va to interact with factor Xa. Results: Elimination of nine amino acids from the B domain results in binding of unactivated factor V to factor Xa. Conclusion: Amino acids 1000-1008 of factor V prevent unwanted prothrombinase assembly. Significance: A short peptide sequence from the Bregion is a regulatory domain for the generation of factor Va procoagulant activity. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.