Mumps virus

Abstract

Newcastle disease virus and Simian virus 5 [4]. Of these, only mumps virus and parainfluenza viruses 2 and 4 are human pathogens. 2.2 Virion Structure and Genome Mumps virions are pleomorphic particles ranging from 100 to 600 nm in size and consisting of a helical ribonucleocapsid core surrounded by a host cell-derived lipid envelope. The virus genome is a nonsegmented, single-stranded RNA macromolecule of negative polarity containing 15,384 nucleotides. The gene order is 3′ N-P-M-F-SH-HN-L 5′, representing the genes for the nucleoprotein, phosphoprotein, matrix protein, fusion protein, small hydrophobic protein, hemagglutinin-neuraminidase protein, and polymerase, respectively [5]. Each gene is translated into a single protein except for the P gene, from which mRNAs are transcribed that encode the phosphoprotein and two nonstructural proteins, V and I [6,7].