Atg14L recruits PtdIns 3-kinase to the ER for autophagosome formation

Abstract

Divergent phosphoinositides are generated to characterize specific organelles and recruit specific effector proteins to these sites. For example, phosphatidylinositol-3-phosphate (PtdIns(3)P) is a typical endosome marker and recruits many types of PtdIns(3)P binding proteins such as EEA1, Hrs and sorting nexins, which are critical in endosomal functions. Likewise, the plasma membrane contains PtdIns(4,5)P2, whereas the Golgi complex has PtdIns(4)P. In this sense, the endoplasmic reticulum is known to be essentially free of phosphoinositide. In other words, this situation provides the ER with the opportunity to recruit whatever proteins are in demand. Recently, we have uncovered how PtdIns(3)P is generated on the ER for the autophagic process. © 2011 Landes Bioscience.