Molecular Simulation of Protein-PEG Interaction

  • Lim K
  • Herron J
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Abstract

Poly(ethylene glycol) (PEG) is a water-soluble polymer that exhibits properties such as protein resistance, low toxicity, and nonimmunogenicity.1--5 These properties have been attributed to its segmental flexibility and its polar, but uncharged, chemical composition. This segmental flexibility produces a high degree of steric exclusion and entropy at PEG-water interfaces which in turn leads to protein resistance. Its exclusion property also enables the precipitation of proteins without denaturation.6--9

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Lim, K., & Herron, J. N. (1992). Molecular Simulation of Protein-PEG Interaction. In Poly(Ethylene Glycol) Chemistry (pp. 29–56). Springer US. https://doi.org/10.1007/978-1-4899-0703-5_3

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