Peptide-induced super-assembly of biocatalytic metal-organic frameworks for programmed enzyme cascades

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Abstract

Despite the promise of metal-organic frameworks (MOFs) as functional matrices for enzyme stabilization, the development of a stimulus-responsive approach to induce a multi-enzyme cascade reaction in MOFs remains a critical challenge. Here, a novel method using peptide-induced super-assembly of MOFs is developed for programmed enzyme cascade reactions on demand. The super-assembled MOF particles containing different enzymes show remarkable 7.3-fold and 4.4-fold catalytic activity enhancements for the two-enzyme and three-enzyme cascade reactions, respectively, as compared with the unassembled MOF nanoparticles. Further digestion of the coiled-coil forming peptides on the MOF surfaces leads to the MOF superstructure disassembly and the programmed enzyme cascade reaction being "switched-off". Research on these stimuli-responsive materials with controllable and predictable biocatalytic functions/properties provide a concept to facilitate the fabrication of next-generation smart materials based on precision chemistry.

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Liang, J., Mazur, F., Tang, C., Ning, X., Chandrawati, R., & Liang, K. (2019). Peptide-induced super-assembly of biocatalytic metal-organic frameworks for programmed enzyme cascades. Chemical Science, 10(34), 7852–7858. https://doi.org/10.1039/c9sc02021g

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