Cutaneous involvement in multiple myeloma (MM) is extremely rare. It may correspond to plasmocytomas, secondary amyloidosis, paraneoplastic syndromes or drug reactions. We report a 75-year-old female with skin lesions, corresponding to extramedullary plasmacytomas (EPs), as a manifestation of MM progression. Most EPs appear in the upper airway and gastrointestinal tract, but have also been described in the genitourinary tract, lung, kidney, thyroid and in 2% of cases, in the skin. Cutaneous lesions are generally associated with terminal stages of the disease and a poor prognosis.
Camila Peña, O., Ximena Valladares, T., Ana María Gray, H., & María Elena Cabrera, C. (2014). Lesiones cutáneas en mieloma múltiple. Descripción de un caso y revisión de la literatura. Revista Medica de Chile, 142(12), 1603–1606. https://doi.org/10.4067/S0034-98872014001200014