Differential mobility spectrometry (DMS) is capable of separating molecules based on their size and shape. When coupled to mass spectrometry (MS), DMS reduces chemical background and enhances signal-to-noise (S/N) ratio. Flow injection analysis (FIA) is a technique used to introduce samples into the source of the DMS-MS platform. Here we describe the application of FIA-DMS-MS/MS for the analysis of urinary acylcarnitine species. More than 20 acylcarnitine species can be detected and quantified during a single FIA-DMS-MS/MS acquisition.
CITATION STYLE
Vera, N. B., Clasquin, M., Coy, S. L., & Vouros, P. (2020). The Use of DMS-MS for the Quantitative Analysis of Acylcarnitines. In Methods in Molecular Biology (Vol. 2084, pp. 95–101). Humana Press Inc. https://doi.org/10.1007/978-1-0716-0030-6_5
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