Site-selectivity in conjugate addition reactions is tightly associated with the principle of vinylogy. Various vinylogous nucleophiles and electrophiles have been applied to stereoselective conjugate additions directed by chiral small molecule catalysts. This chapter focuses on the systems that control site- and stereoselectivity via chiral ion-pairing intermediates under organocatalytic conditions and describes individual vinylogous substrates in a separate section. Although site-selectivity originates largely from the intrinsic stereoelectronic nature of individual substrates, catalyst-controlled site-selectivity can be attained in certain cases.
CITATION STYLE
Uraguchi, D., & Ooi, T. (2015). Site-selective conjugate addition through catalytic generation of ion-pairing intermediates. Topics in Current Chemistry, 372, 55–83. https://doi.org/10.1007/128_2015_655
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