Enantioselective ring expansion of prolinols and ring-closing metathesis: Formal synthesis of (-)-swainsonine

Abstract

An efficient enantioselective formal synthesis of (-)-swainsonine has been achieved in 14 steps with 14% global yield using an enantioselective ring enlargement of a substituted prolinol and a ring-closing metathesis as the key steps. ©ARKAT.