Objective . Zinc- α 2-glycoprotein (ZAG) has recently been proposed as a new adipokine involved in body weight regulation. The purpose of this study is to investigate serum levels of ZAG in patients with hypertension and its association with related characteristics. Methods . 32 hypertension patients and 42 normal controls were recruited and the relationship between serum ZAG, total and high molecular weight (HMW) adiponectin, and tumor necrosis factor- α (TNF α ) determined by enzyme-linked immunosorbent assay (ELISA) and metabolic-related parameters was investigated. Results . Serum ZAG concentrations were significantly lowered in patients with hypertension compared with healthy controls (61.4 ± 32 versus 78.3 ± 42 μ g/mL, P < 0.05 ). The further statistical analysis demonstrated that serum ZAG levels were negatively correlated with waist-to-hip ratio (WHR) ( r = − 0.241 , P < 0.05 ) and alanine aminotransferase (ALT) ( r = − 0.243 , P < 0.05 ). Additionally, serum HMW adiponectin significantly decreased, while TNF α greatly increased in hypertension patients as compared with healthy controls (2.32 ± 0.41 versus 5.24 ± 1.02 μ g/mL, 3.30 ± 1.56 versus 2.34 ± 0.99 pg/mL, P < 0.05 ). Conclusions . Serum ZAG levels are significantly lowered in hypertension patients and negatively correlated with obesity-related item WHR, suggesting ZAG is a factor associated with hypertension.
CITATION STYLE
Zhu, H. J., Wang, X. qing, Pan, H., Gong, F. ying, Zhang, D. xi, Li, N. shi, … Yang, H. bo. (2014). Serum Levels of the Adipokine Zinc- α 2-glycoprotein Are Decreased in Patients with Hypertension. ISRN Endocrinology, 2014, 1–8. https://doi.org/10.1155/2014/374090
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