Many antimicrobial peptides are considered to kill microbes by permeabilizing cell membranes. This chapter summarizes the driving force of peptide binding to membranes; various mechanisms of lipid bilayer permeabilization including the barrel-stave, toroidal pore, and carpet models; and modes of permeabilization of bacterial and mammalian membranes.
CITATION STYLE
Matsuzaki, K. (2019). Membrane permeabilization mechanisms. In Advances in Experimental Medicine and Biology (Vol. 1117, pp. 9–16). Springer New York LLC. https://doi.org/10.1007/978-981-13-3588-4_2
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